Mitochondria-targeted ROS scavenger JP4-039 improves cardiac function in a post-myocardial infarction animal model and induces angiogenesis in vitro
JP4-039-mediated reduction in mito-ROS results in significantly increased coronary vascular density in ischemic myocardium, improved ATP synthesis, and recovery of post-MI cardiac function. Together, these results suggest that nitroxide nanodrug-mediated reduction in mito-ROS may help recover post-MI cardiac function.
Authors
- Aja Tucker (ORCID: https://orcid.org/0000-0002-9610-8504)
- Frank W. Sellke (ORCID: https://orcid.org/0000-0002-8886-801X)
- Peter Wipf (ORCID: https://orcid.org/0000-0001-7693-5863)
- M. Ruhul Abid (ORCID: https://orcid.org/0000-0003-2981-2638)
- Rayane Brinck Teixeira (ORCID: https://orcid.org/0000-0001-9749-6580)
- Mohamed Sabra (ORCID: https://orcid.org/0000-0001-8336-9783)
- T. Abedin
- Jane H Albro
- Raj Sidharth
Institutions
- University of Pittsburgh (US)
- Brown University (US)
- Rhode Island Hospital (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1371/journal.pone.0320703
- Citations
- 4
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 5.89
Funders
- Rhode Island Foundation
- National Heart, Lung, and Blood Institute