Optic Nerve Sheath Meningiomas in Children: Diagnostic Challenges Based on a Case Series
The diagnosis of optic nerve sheath meningiomas (ONSM) in children and teenagers remains challenging despite advances in high-quality imaging. We identified seven children diagnosed with ONSM in four tertiary paediatric oncology centres in the United Kingdom. Our case series highlighted the value of PET-DOTATATE scans in assisting diagnosis when biopsy was considered high risk. Computed tomography (CT) scan may be useful for demonstrating calcification within the meningioma, a relatively specific finding occurring in 20%-50% of ONSM cases. Unfortunately, despite optimal treatment, vision loss is unavoidable in some patients. To improve outcomes, prompt consultation with a multidisciplinary team is recommended.
Authors
- Harpreet Hyare (ORCID: https://orcid.org/0000-0002-4672-3349)
- Andrzej Brodkiewicz (ORCID: https://orcid.org/0000-0001-7951-8969)
- Darren Hargrave (ORCID: https://orcid.org/0000-0001-8219-9807)
- Mette Jørgensen (ORCID: https://orcid.org/0000-0002-2804-0560)
- George Lawson (ORCID: https://orcid.org/0000-0001-5968-0010)
- John Apps (ORCID: https://orcid.org/0000-0001-7902-482X)
- Sarita Depani (ORCID: https://orcid.org/0000-0001-7762-686X)
- Sam Gurney (ORCID: https://orcid.org/0000-0002-7028-7014)
- Sucheta Vaidya (ORCID: https://orcid.org/0000-0003-2980-9316)
- Elwira Szychot (ORCID: https://orcid.org/0000-0002-1598-7018)
- Carmen Soto (ORCID: https://orcid.org/0000-0002-6323-3069)
- Jarosław Peregud‐Pogorzelski (ORCID: https://orcid.org/0000-0003-2634-6002)
- Owase Jeelani (ORCID: https://orcid.org/0000-0002-3240-681X)
- Ian Reekie (ORCID: https://orcid.org/0000-0003-2542-7329)
- Kavitha Srivatsa
- Deysha Ratnasingham
Institutions
- University College Hospital (GB)
- Great Ormond Street Hospital (GB)
- Birmingham Children's Hospital (GB)
- Royal Marsden Hospital (GB)
- University College London (GB)
- Pomeranian Medical University (PL)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1002/pbc.31739
- Citations
- 1
- Primary Topic
- Meningioma and schwannoma management
- Type
- article
- Field-Weighted Citation Impact
- 1.35