Dupilumab, a Novel Treatment for Peripheral Neuropathy: A Case Series

Peripheral neuropathy is a chronic neurological disorder that can present with a multitude of symptoms. It is observed in association with various disease states and organ systems. In the process of treatment for atopic dermatitis, we have observed that patients reported improvements in their previously diagnosed neuropathies, essentially, relief from neuropathic symptoms such as burning, itching, or tingling. On the basis of these observations, we conducted a single-arm trial to survey the qualitative changes in patients with peripheral neuropathy. Ten patients with atopic dermatitis with previously diagnosed peripheral neuropathies were treated with dupilumab (DP) and observed for symptom changes over 6 months. A paired t-test was used to determine whether DP might potentially be used as an off-label treatment for patients with peripheral neuropathy and dermatological conditions. Our patients showed significant symptom relief, thus suggesting that further investigation of the use of DP for patients with neuropathies is warranted.