A new protein isoform encoded by human circular RNA circSLC8a1 contributes to cardiac remodelling
Our study provides evidence that circSLC8a1 has the capacity to encode a novel protein isoform, SLC8a1-604, which plays a pivotal role in the regulation of heart functions: circSLC8a1 modulates the remodelling process of cardiac pressure overload by translating into a functional protein.
Authors
- Nan Wu (ORCID: https://orcid.org/0000-0002-9063-4028)
- Jinfeng Wei (ORCID: https://orcid.org/0000-0003-0850-1312)
- Jindong Xu (ORCID: https://orcid.org/0000-0002-3419-6561)
- Feiya Li (ORCID: https://orcid.org/0000-0001-6585-5171)
- Shuo‐Yang Wen (ORCID: https://orcid.org/0000-0001-5533-0638)
- Xiangmin Li (ORCID: https://orcid.org/0000-0003-3515-4774)
- Qiwei Yang (ORCID: https://orcid.org/0000-0003-0681-2184)
- Javeria Qadir (ORCID: https://orcid.org/0000-0001-7200-3778)
- Sheng Wang (ORCID: https://orcid.org/0000-0002-5718-7529)
- William W. Du
Institutions
- Sunnybrook Health Science Centre (CA)
- Capital Medical University (CN)
- University of Toronto (CA)
- Guangdong Academy of Sciences (CN)
- Beijing Anzhen Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Sunnybrook Hospital (CA)
- Institute of Medical Sciences (IN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1093/cvr/cvaf058
- Citations
- 5
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Canadian Institutes of Health Research