<scp>TTX</scp>‐R and <scp>TTX</scp>‐S Sodium Channels in <scp>CGRP</scp>‐Positive Dorsal Root Ganglia Neurons Mediate Referred Somatic Hyperalgesia in Ulcerative Colitis Mice
The functional alterations in Na<sub>v</sub>1.8 and Na<sub>v</sub>1.7 channels within CGRP<sup>+</sup> DRG neurons are pivotal to the development of neurogenic inflammation and referred somatic hyperalgesia. These findings lay a foundation for exploring novel therapeutic targets to relieve visceral referred pain.
Authors
- Haifa Qiao (ORCID: https://orcid.org/0000-0001-6456-7426)
- Zhijun Diao
- Yu‐Wei Wu (ORCID: https://orcid.org/0000-0002-4459-087X)
- Yongbin Liu (ORCID: https://orcid.org/0000-0001-5211-4278)
- Ziyan Yuan
- He Hongzhou
- Simeng Xue
- Huanhuan Liu
Institutions
- Shaanxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Neurogastroenterology & Motility
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1111/nmo.70051
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China