Multimodal imaging analysis of autosomal recessive Parkinson’s disease
AR-PD group showed additional significant decreased 18F-DOPA uptake in caudate corpus and more symmetrical striatal denervation. Additionally, relatively preserved myocardial innervation, cortical metabolic and WM microstructural changes suggest the possibility of "brain-first" type progression in AR-PD. Also, 18F-DOPA PET/CT may be a practical tool for evaluating dopaminergic innervation of striatum and heart together, but further evaluation is needed in this area.
Authors
- Ömer Uğur (ORCID: https://orcid.org/0000-0003-2248-5232)
- Hacer Dasgin
- Kader Karlı Oğuz (ORCID: https://orcid.org/0000-0002-3385-4665)
- Bilge Volkan Salancı (ORCID: https://orcid.org/0000-0002-1488-6012)
- Başak Soydaş Turan (ORCID: https://orcid.org/0000-0003-3425-751X)
- Gül Yalçın Çakmaklı (ORCID: https://orcid.org/0000-0001-8545-7939)
- Eser Lay Ergün (ORCID: https://orcid.org/0000-0002-1847-965X)
- Bülent Elibol (ORCID: https://orcid.org/0000-0001-5015-0152)
Institutions
- Bilkent University (TR)
- Bursa Technical University (TR)
- Institute of Neurological Sciences (IT)
- University of California Davis Medical Center (US)
- Hacettepe University (TR)
- Kastamonu University (TR)
Publication Details
- Journal
- Annals of Nuclear Medicine
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1007/s12149-025-02053-4
- Citations
- 1
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Hacettepe Üniversitesi