Patterns and Prevalence of Food Allergen Cross-Reactivity: A Cross-Sectional Study of Food-Allergic Adults in the Makkah Region, Saudi Arabia

This study highlights a high prevalence of food allergen cross-reactivity among adults in the Makkah region, with significant gender- and age-related trends. The findings underscore the need for clinician awareness of atypical and panallergen-driven cross-reactivity to support tailored patient counseling and management strategies. Region-specific screening protocols and culturally informed public health campaigns are recommended to address local dietary practices and improve allergy awareness. Future longitudinal and interventional studies incorporating objective diagnostic tools are essential to validate these findings and assess the effectiveness of targeted interventions. These insights can inform clinical guidelines and national health policies to improve diagnosis, treatment, and patient education in Saudi Arabia.