Aqueous Polygalae Radix extract (PRE) prolongs the lifespan of C. elegans and alleviates D-galactose-induced oxidative stress in the mouse liver and brain by modulating PPARγ/MAPK
PRE delays aging and resists oxidative stress in organisms; it may act by regulating the PPARγ/MAPK signaling pathway and the intestinal flora. The efficacy and mechanism of PRE against oxidative stress were elucidated using RNA-seq and 16S rDNA sequencing, providing a reference for antiaging and aging-related diseases.
Authors
- Qianhua Zhang
- Yu Wei (ORCID: https://orcid.org/0000-0001-8473-6856)
- Zhengjie Zhou (ORCID: https://orcid.org/0000-0001-8329-6086)
- Yu An (ORCID: https://orcid.org/0000-0002-9678-3382)
- Fang Wang (ORCID: https://orcid.org/0000-0003-0871-3454)
- Yanan Zhang (ORCID: https://orcid.org/0000-0001-7153-4358)
- Jingtong Zheng (ORCID: https://orcid.org/0000-0003-4615-3734)
- Wenxue Zheng
- Jiaqi Zhang (ORCID: https://orcid.org/0000-0002-7449-4176)
- Haoyu Zheng
Institutions
- Jilin University (CN)
- Jilin Medical University (CN)
- First Bethune Hospital of Jilin University (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1016/j.jep.2025.119878
- Citations
- 4
- Primary Topic
- Antioxidants, Aging, Portulaca oleracea
- Type
- article
- Field-Weighted Citation Impact
- 3.64
Funders
- Jilin Scientific and Technological Development Program
- Program for Jilin University Science and Technology Innovative Research Team