Cell-type-specific and inflammatory DNA methylation patterns associated with PTSD
This study identifies novel PTSD-associated CpGs in individual immune cell types and supports the role of immune dysregulation and inflammation in PTSD.
Authors
- Mark W. Miller (ORCID: https://orcid.org/0000-0001-6393-8563)
- Ying Zhao (ORCID: https://orcid.org/0000-0001-6781-092X)
- Agaz H. Wani (ORCID: https://orcid.org/0000-0002-0540-2952)
- Jasmeet P. Hayes (ORCID: https://orcid.org/0000-0002-5157-0666)
- Negar Fani (ORCID: https://orcid.org/0000-0002-7720-252X)
- Elbert Geuze (ORCID: https://orcid.org/0000-0003-3479-2379)
- Allison E. Aiello (ORCID: https://orcid.org/0000-0001-7029-2537)
- Abigail Powers (ORCID: https://orcid.org/0000-0003-3197-7415)
- Holly K. Orcutt (ORCID: https://orcid.org/0000-0002-0197-0784)
- Nicole R. Nugent (ORCID: https://orcid.org/0000-0001-8756-5618)
- Mark W. Logue (ORCID: https://orcid.org/0000-0001-9347-7892)
- Caroline M. Nievergelt (ORCID: https://orcid.org/0000-0001-5766-8923)
- Charles F. Gillespie (ORCID: https://orcid.org/0000-0001-5476-5920)
- Mieke Verfaellie (ORCID: https://orcid.org/0000-0001-5535-4584)
- Sheila A. M. Rauch (ORCID: https://orcid.org/0000-0001-9686-4011)
- Karestan C. Koenen (ORCID: https://orcid.org/0000-0003-2978-7655)
- Bart P. F. Rutten (ORCID: https://orcid.org/0000-0002-9834-6346)
- Adam X. Maihofer (ORCID: https://orcid.org/0000-0003-4517-1623)
- Christiaan H. Vinkers (ORCID: https://orcid.org/0000-0003-3698-0744)
- Shareefa Dalvie (ORCID: https://orcid.org/0000-0003-2333-4823)
- Mary Sophia Mufford (ORCID: https://orcid.org/0000-0002-8409-9217)
- Chia‐Yen Chen (ORCID: https://orcid.org/0000-0001-9548-5597)
- William Milberg (ORCID: https://orcid.org/0000-0002-6078-7066)
- Marco P. Boks (ORCID: https://orcid.org/0000-0001-6163-7484)
- Eric Vermetten (ORCID: https://orcid.org/0000-0003-0579-4404)
- Joel Gelernter (ORCID: https://orcid.org/0000-0002-4067-1859)
- Şeyma Katrinli (ORCID: https://orcid.org/0000-0003-1575-8642)
- Samuel A. McLean (ORCID: https://orcid.org/0000-0001-9482-3582)
- Ronald C. Kessler (ORCID: https://orcid.org/0000-0003-4831-2305)
- Nastassja Koen (ORCID: https://orcid.org/0000-0002-1119-8142)
- Leslie A. Brick (ORCID: https://orcid.org/0000-0002-1877-2493)
- Derek E. Wildman (ORCID: https://orcid.org/0000-0002-6374-5136)
- Sarah D. Linnstaedt (ORCID: https://orcid.org/0000-0001-5295-7072)
- Erika J. Wolf (ORCID: https://orcid.org/0000-0003-2666-2435)
- Victoria B. Risbrough (ORCID: https://orcid.org/0000-0001-8347-3820)
- Dan Joseph Stein (ORCID: https://orcid.org/0000-0001-7218-7810)
- Murray B. Stein (ORCID: https://orcid.org/0000-0001-9564-2871)
- Israel Liberzon (ORCID: https://orcid.org/0000-0002-4990-556X)
- Vasiliki Michopoulos (ORCID: https://orcid.org/0000-0003-2531-923X)
- Catherine B. Fortier (ORCID: https://orcid.org/0000-0002-8953-9904)
- Robert J. Ursano (ORCID: https://orcid.org/0000-0002-1861-9173)
- Alicia K. Smith (ORCID: https://orcid.org/0000-0002-8537-5156)
- Anthony P. King (ORCID: https://orcid.org/0000-0002-0764-9625)
- Dewleen G. Baker (ORCID: https://orcid.org/0000-0002-1736-9838)
- Anthony S. Zannas (ORCID: https://orcid.org/0000-0002-6897-9652)
- Suzi Hong (ORCID: https://orcid.org/0000-0003-0300-5950)
- Jordan W. Smoller
- Kerry J. Ressler
- Monica Uddin
- Erin B WareVinkers
Institutions
- Northern Illinois University (US)
- Broad Institute (US)
- Boston University (US)
- University of North Carolina at Chapel Hill (US)
- Biogen (United States) (US)
- Western Cape Department of Health (ZA)
- Harvard University (US)
- Uniformed Services University of the Health Sciences (US)
- Emory University (US)
- University of Cape Town (ZA)
- University of South Florida (US)
- Brown University (US)
- University of Michigan (US)
- Leiden University Medical Center (NL)
- McLean Hospital (US)
- VA Boston Healthcare System (US)
- Maastricht University (NL)
- University of California San Diego (US)
- VA Connecticut Healthcare System (US)
- Massachusetts General Hospital (US)
- Ministry of Defence (NL)
- Dimence (NL)
- VA San Diego Healthcare System (US)
- National Center for PTSD (US)
- Amsterdam Neuroscience (NL)
- Human Longevity (United States) (US)
- Institute for Behavioral Medicine (US)
- Atlanta VA Health Care System (US)
- The Ohio State University (US)
- Columbia University (US)
- University of the Western Cape (ZA)
- Florida College (US)
- Bryan College (US)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1016/j.bbi.2025.04.031
- Citations
- 5
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- U.S. Department of Defense
- U.S. Department of Justice
- U.S. Department of Veterans Affairs
- Bill and Melinda Gates Foundation
- Brain Research Foundation
- Sanofi
- Biogen
- One Mind
- Foundation of Hope for Research and Treatment of Mental Illness
- Vistagen Therapeutics
- University of Oxford
- South African Medical Research Council
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Servier
- H. Lundbeck A/S
- National Institutes of Health
- Medical Research Council
- National Institute of Mental Health
- Medical Research and Materiel Command