Cell-type-specific and inflammatory DNA methylation patterns associated with PTSD

This study identifies novel PTSD-associated CpGs in individual immune cell types and supports the role of immune dysregulation and inflammation in PTSD.

Authors

Institutions

Publication Details

Journal
Brain Behavior and Immunity
Published
2025-04-24
DOI
https://doi.org/10.1016/j.bbi.2025.04.031
Citations
5
Primary Topic
Epigenetics and DNA Methylation
Type
article
Field-Weighted Citation Impact
4.03

Funders

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article

Cell-type-specific and inflammatory DNA methylation patterns associated with PTSD

Mark W. Miller, Ying Zhao, Agaz H. Wani, Jasmeet P. Hayes et al.
5 citations
Brain Behavior and Immunity
Epigenetics and DNA Methylation
4.03
article

Cell-type-specific and inflammatory DNA methylation patterns associated with PTSD

Mark W. Miller, Ying Zhao, Agaz H. Wani, Jasmeet P. Hayes, Negar Fani, Elbert Geuze, Allison E. Aiello, Abigail Powers, Holly K. Orcutt, Nicole R. Nugent, Mark W. Logue, Caroline M. Nievergelt, Charles F. Gillespie, Mieke Verfaellie, Sheila A. M. Rauch, Karestan C. Koenen, Bart P. F. Rutten, Adam X. Maihofer, Christiaan H. Vinkers, Shareefa Dalvie, Mary Sophia Mufford, Chia‐Yen Chen, William Milberg, Marco P. Boks, Eric Vermetten, Joel Gelernter, Şeyma Katrinli, Samuel A. McLean, Ronald C. Kessler, Nastassja Koen, Leslie A. Brick, Derek E. Wildman, Sarah D. Linnstaedt, Erika J. Wolf, Victoria B. Risbrough, Dan Joseph Stein, Murray B. Stein, Israel Liberzon, Vasiliki Michopoulos, Catherine B. Fortier, Robert J. Ursano, Alicia K. Smith, Anthony P. King, Dewleen G. Baker, Anthony S. Zannas, Suzi Hong, Jordan W. Smoller, Kerry J. Ressler, Monica Uddin, Erin B WareVinkers
article en
5 citations

Abstract

This study identifies novel PTSD-associated CpGs in individual immune cell types and supports the role of immune dysregulation and inflammation in PTSD.

Brain Behavior and ImmunityVol. 128
Northern Illinois University (US), Broad Institute (US), Boston University (US), University of North Carolina at Chapel Hill (US), Biogen (United States) (US), Western Cape Department of Health (ZA), Harvard University (US), Uniformed Services University of the Health Sciences (US), Emory University (US), University of Cape Town (ZA), University of South Florida (US), Brown University (US), University of Michigan (US), Leiden University Medical Center (NL), McLean Hospital (US), VA Boston Healthcare System (US), Maastricht University (NL), University of California San Diego (US), VA Connecticut Healthcare System (US), Massachusetts General Hospital (US), Ministry of Defence (NL), Dimence (NL), VA San Diego Healthcare System (US), National Center for PTSD (US), Amsterdam Neuroscience (NL), Human Longevity (United States) (US), Institute for Behavioral Medicine (US), Atlanta VA Health Care System (US), The Ohio State University (US), Columbia University (US), University of the Western Cape (ZA), Florida College (US), Bryan College (US)
U.S. Department of Defense, U.S. Department of Justice, U.S. Department of Veterans Affairs, Bill and Melinda Gates Foundation, Brain Research Foundation, Sanofi, Biogen, One Mind, Foundation of Hope for Research and Treatment of Mental Illness, Vistagen Therapeutics, University of Oxford, South African Medical Research Council, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Servier, H. Lundbeck A/S, National Institutes of Health, Medical Research Council, National Institute of Mental Health, Medical Research and Materiel Command
Gender equality
Openalex Percentile: Top 6%
Epigenetics and DNA Methylation
4.03
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