Tau profiling across Alzheimer’s disease staging reveals vulnerability to disease pathophysiology
Stage system based on tau load and spreading profiles across cortical areas provide a compelling framework for inferring pathophysiological prognosis in Alzheimer's disease.
Authors
- Yasser Iturria‐Medina (ORCID: https://orcid.org/0000-0002-9345-0347)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Mira Chamoun (ORCID: https://orcid.org/0000-0001-7001-5652)
- Joseph Therriault (ORCID: https://orcid.org/0000-0002-7826-4781)
- Paolo Vitali (ORCID: https://orcid.org/0000-0001-8953-1542)
- Mélissa Savard
- Min Su Kang
- Gassan Massarweh (ORCID: https://orcid.org/0000-0003-2259-9627)
- Jean‐Paul Soucy (ORCID: https://orcid.org/0000-0001-6979-1259)
- Sulantha Mathotaarachchi (ORCID: https://orcid.org/0000-0001-9391-4503)
- Jaime Fernandez‐Arias
- Vanessa Pallen
- Nesrine Rahmouni (ORCID: https://orcid.org/0009-0004-3081-8468)
- Arthur C. Macedo (ORCID: https://orcid.org/0000-0002-3957-0284)
- Thomas K. Karikari (ORCID: https://orcid.org/0000-0003-1422-4358)
- Peter Kunach (ORCID: https://orcid.org/0000-0001-7428-6812)
- Brandon J. Hall (ORCID: https://orcid.org/0009-0007-4578-2033)
- Tatsuhiro Terada (ORCID: https://orcid.org/0000-0002-0783-5508)
- Stijn Servaes (ORCID: https://orcid.org/0000-0003-3565-1930)
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Julie Ottoy (ORCID: https://orcid.org/0000-0002-9879-7497)
- Cécile Tissot (ORCID: https://orcid.org/0000-0003-2711-3833)
- Étienne Aumont (ORCID: https://orcid.org/0000-0002-8997-7090)
- Gleb Bezgin (ORCID: https://orcid.org/0000-0002-1069-9201)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Yi-Ting Wang (ORCID: https://orcid.org/0000-0001-7509-2016)
- Alyssa Stevenson
- Nicholas J. Ashton
- Andréa Lessa Benedet
- Seyyed Ali Hosseini
- Serge Gauthier
- Jenna Stevenson (ORCID: https://orcid.org/0000-0003-2848-1451)
- Kaj Blennow
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0002-4671-6763)
- Nina Margherita Poltronetti
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- University of Pittsburgh (US)
- University of Toronto (CA)
- Sahlgrenska University Hospital (SE)
- McGill University Health Centre (CA)
- Hamamatsu University School of Medicine (JP)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- McGill University (CA)
- University of Gothenburg (SE)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1007/s00259-025-07257-4
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Eli Lilly and Company
- Biogen
- Familjen Erling-Perssons Stiftelse
- Fondation Brain Canada
- Stiftelsen för Gamla Tjänarinnor
- Weston Brain Institute
- EU Joint Programme – Neurodegenerative Disease Research
- Consortium canadien en neurodégénérescence associée au vieillissement
- Cerveau Technologies
- European Commission
- Hjärnfonden
- Vetenskapsrådet
- Julius Clinical
- UK Dementia Research Institute
- National Institutes of Health
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé