Ubiquitin-like with phd and ring finger domains 1 as a potential therapeutic target in smoking-associated oral squamous cell carcinoma
This study provides the first evidence that UHRF1 functions as an oncogenic driver in OSCC and may mediate smoking-induced tumorigenesis. These findings highlight UHRF1 as a potential biomarker and therapeutic target, particularly in smoking-associated OSCC.
Authors
- Chi‐Hsiao Yeh
- Alexander Cheng-Ting Hsieh
- Yi‐Jen Hung (ORCID: https://orcid.org/0000-0001-5318-9001)
- Chung‐Cheng Chen (ORCID: https://orcid.org/0000-0003-1114-0255)
- Yi‐Shing Shieh (ORCID: https://orcid.org/0000-0001-7000-091X)
- Che-Yi Lin (ORCID: https://orcid.org/0000-0002-7719-2325)
- Tsai-Wang Huang (ORCID: https://orcid.org/0000-0001-8741-9223)
- Chu‐Yen Chien
- Jia‐Rong Wu (ORCID: https://orcid.org/0000-0003-0696-4356)
Institutions
- Tri-Service General Hospital (TW)
- Kaohsiung Medical University (TW)
- Chi Mei Medical Center (TW)
- National Defense Medical Center (TW)
- Academia Sinica (TW)
Publication Details
- Journal
- Journal of Dental Sciences
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1016/j.jds.2025.04.011
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and Technology, Taiwan
- Chi Mei Medical Center
- Tri-Service General Hospital