Global, regional, and national impact of Down syndrome on child and adolescent mortality from 1980 to 2021, with projections to 2050: a cross-sectional study

Most countries have seen a decline in Down syndrome deaths among children and adolescents over the last 42 years, but a few high SDI countries are witnessing an increase. Future health interventions should prioritize these countries, focusing on resource allocation, infrastructure, and health education. Continued efforts on care for the 0-4 age group with Down syndrome are crucial to further reducing deaths in this age group.