Brown adipose tissue-derived extracellular vesicles regulate hepatocyte mitochondrial activity to alleviate high-fat diet-induced jawbone osteoporosis in mice
This study establishes LMD as a crucial driver factor in JOP and identifies BEV-mediated mitochondrial transferring in hepatocytes as a therapeutic strategy for LMD-related JOP.
Authors
- Yu Fu (ORCID: https://orcid.org/0000-0002-1203-6970)
- Guorong Deng (ORCID: https://orcid.org/0000-0001-5804-1356)
- Zhen Gong (ORCID: https://orcid.org/0000-0002-1219-0476)
- Chenxi Zheng (ORCID: https://orcid.org/0009-0003-9490-3031)
- Kai Zhang (ORCID: https://orcid.org/0000-0002-8292-8683)
- Guangxiang He
- Liang Kong (ORCID: https://orcid.org/0000-0003-4960-1993)
- Sha Zhang (ORCID: https://orcid.org/0000-0003-1175-6770)
- Yihan Liu (ORCID: https://orcid.org/0000-0001-9094-0693)
- Yuan Yuan (ORCID: https://orcid.org/0000-0002-4011-1042)
Institutions
- Chinese PLA General Hospital (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Shaanxi University of Chinese Medicine (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-04-24
- DOI
- https://doi.org/10.3389/fendo.2025.1583408
- Citations
- 2
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.33