Impaired efferocytosis by monocytes and monocyte-derived macrophages in patients with poorly controlled type 2 diabetes
Impaired efferocytosis was observed in T2D patients, with poor glycemic control affecting both blood monocytes and monocyte-derived macrophages. The efferocytosis index was negatively associated with metrics of glycemic control, and glucotoxicity may impact efferocytosis through reducing CD14 expression on both monocytes and macrophages.
Authors
- Yixin Niu (ORCID: https://orcid.org/0000-0001-9413-2255)
- Zhongxing Chu (ORCID: https://orcid.org/0009-0009-7078-2267)
- Qianyun Mao
- Sunyue He (ORCID: https://orcid.org/0000-0002-4475-212X)
- Qiuyue Hu (ORCID: https://orcid.org/0009-0004-7776-8883)
- Yisheng Chai (ORCID: https://orcid.org/0000-0003-0034-7488)
- Qing Su (ORCID: https://orcid.org/0000-0001-7945-1258)
- Hongmei Zhang (ORCID: https://orcid.org/0000-0002-4068-7017)
- Qian Xu (ORCID: https://orcid.org/0000-0001-9262-3595)
- Xiaoyong Li (ORCID: https://orcid.org/0000-0001-7754-731X)
- Yao Lu (ORCID: https://orcid.org/0000-0002-2169-6479)
- Hui Ran (ORCID: https://orcid.org/0000-0001-6626-7531)
- Weijing Ding (ORCID: https://orcid.org/0009-0004-0075-6665)
- Han Li (ORCID: https://orcid.org/0000-0002-7429-0616)
Institutions
- Shanghai Jiao Tong University (CN)
- XinHua Hospital (CN)
Publication Details
- Journal
- World Journal of Diabetes
- Published
- 2025-04-24
- DOI
- https://doi.org/10.4239/wjd.v16.i5.101473
- Citations
- 1
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.80