Shenfushu granules attenuate diabetic kidney disease by inhibiting <i>PIK3R1</i>/protein kinase B/heparanase-mediated endothelial-mesenchymal transition
Collectively, these results suggest that SFSGs can significantly delay DKD progression and inhibit injury to the glycocalyx and the endothelial-mesenchymal transition of glomerular endothelial cells. This mechanism is related to <i>PIK3R1</i>/AKT/heparanase-1 signaling pathway regulation.
Authors
- Daxiong Xiang (ORCID: https://orcid.org/0000-0002-4226-6574)
- Xi‐Ding Yang (ORCID: https://orcid.org/0000-0001-5489-6058)
- Sijia Ma (ORCID: https://orcid.org/0000-0002-3978-4346)
- Yong‐Yu Yang
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- World Journal of Diabetes
- Published
- 2025-04-24
- DOI
- https://doi.org/10.4239/wjd.v16.i5.102196
- Primary Topic
- Lipid metabolism and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00