Endoplasmic reticulum stress and forkhead box protein O1 inhibition mediate palmitic acid and high glucose-induced β-cell dedifferentiation
ER stress is sufficient to trigger β-cell dedifferentiation and is necessary for palmitic acid and high glucose-induced β-cell dedifferentiation. Foxo1 inhibition can further enhance these phenomena.
Authors
- Ting-Yan Yu
- Yang Lu (ORCID: https://orcid.org/0000-0003-3380-5916)
- Hongmao Sun
- Ying Hui Sun (ORCID: https://orcid.org/0000-0002-2570-9206)
- Mingyu Li (ORCID: https://orcid.org/0000-0003-1217-2929)
- Wei Wang (ORCID: https://orcid.org/0000-0001-6853-7785)
- Likun Wang (ORCID: https://orcid.org/0000-0003-3767-7368)
- Chu-Chu Kong
Institutions
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
Publication Details
- Journal
- World Journal of Diabetes
- Published
- 2025-04-24
- DOI
- https://doi.org/10.4239/wjd.v16.i5.95431
- Citations
- 2
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 4.01