Single-nucleotide polymorphisms in genes involved in folate metabolism or selected other metabolites and risk for gestational diabetes mellitus
This study does not find an association between SNPs of folate metabolic enzymes and risk for GDM. The G mutant allele of <i>MTNR1B</i> rs10830963 is identified as a risk factor for GDM in the additive model, and there may be gene-gene interactions between <i>MTNR1B</i> rs10830963 and <i>CHEMERIN</i> rs4721. It is conducive to studying the causes of GDM and provides a new perspective for the precise prevention of this disease.
Authors
- Bo Young Hong (ORCID: https://orcid.org/0000-0001-9290-6173)
- Jiahe Liu (ORCID: https://orcid.org/0009-0003-5971-8711)
- Shaowei Wu (ORCID: https://orcid.org/0000-0003-2680-6064)
- Weitai Huang (ORCID: https://orcid.org/0000-0001-7809-8819)
- Qi Wang (ORCID: https://orcid.org/0000-0002-5287-6050)
- Di Wang (ORCID: https://orcid.org/0000-0002-6221-0949)
- Lei Chen (ORCID: https://orcid.org/0009-0008-7510-5583)
- Lei Jin (ORCID: https://orcid.org/0000-0003-0367-7765)
- Sisi Li (ORCID: https://orcid.org/0000-0003-4870-3840)
- Jie Zhang (ORCID: https://orcid.org/0000-0001-9210-4154)
- Tingting Zheng (ORCID: https://orcid.org/0000-0002-1437-2062)
- Chun-Yi Liu (ORCID: https://orcid.org/0000-0002-3395-4906)
Institutions
- Peking University (CN)
- National Health and Family Planning Commission (CN)
Publication Details
- Journal
- World Journal of Diabetes
- Published
- 2025-04-24
- DOI
- https://doi.org/10.4239/wjd.v16.i5.103602
- Citations
- 1
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 1.67