Variability of Argatroban Effects on the Multiple <scp>APTT</scp> Reagents in High and Low Coagulation Activity Samples
A reactivity difference was observed in argatroban-spiked samples, which increased in abnormal plasma samples. APTT may not reflect the anticoagulant activity of argatroban in patients with abnormal coagulation activity. The reactivity of APTT should be confirmed in each laboratory, and patient background coagulation status should be assessed before monitoring is conducted using the APTT ratio.
Authors
- Teruto Hashiguchi (ORCID: https://orcid.org/0000-0003-4820-8268)
- Satoshi Yamazaki (ORCID: https://orcid.org/0000-0003-4249-3854)
- Masako Yamazaki (ORCID: https://orcid.org/0000-0003-4989-7974)
- Masahiro Ieko (ORCID: https://orcid.org/0000-0003-1854-4543)
- Osamu Kumano (ORCID: https://orcid.org/0000-0001-6650-0567)
- Takashi Ito (ORCID: https://orcid.org/0000-0002-6204-8400)
- Sumiyoshi Naito
Institutions
- Kagoshima University (JP)
- Chiba University (JP)
- Health Sciences University of Hokkaido (JP)
- St. Marianna University School of Medicine (JP)
- Sapporo University (JP)
- National Institute of Advanced Industrial Science and Technology (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- International Journal of Laboratory Hematology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1111/ijlh.14488
- Primary Topic
- Heparin-Induced Thrombocytopenia and Thrombosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00