Multi-target neuroprotection by dl-PHPB in APP/PS1 mice: a proteomic analysis

Our results revealed 11 altered proteins in the cortex and 10 in the hippocampus between the WT and APP/PS1 groups treated with vehicle. Following dl-PHPB treatment, 12 differentially expressed proteins were identified in the cortex and 9 in the hippocampus of APP/PS1 mice. These proteins are primarily involved in energy metabolism, neuronal structure, protein trafficking, inflammatory and oxidative responses, and amyloid β (Aβ) and Tau processes, among which several proteins were validated as potential therapeutic targets. Notably, the expression levels of cofilin-2 and VDAC1 in APP/PS1 mice were restored to near-normal levels by the treatment with dl-PHPB, memantine, or donepezil, and further clinical validation is required to establish their utility as AD biomarkers for therapeutic efficacy.

Authors

Institutions

Publication Details

Journal
Frontiers in Pharmacology
Published
2025-04-24
DOI
https://doi.org/10.3389/fphar.2025.1554168
Citations
1
Primary Topic
Signaling Pathways in Disease
Type
article
Field-Weighted Citation Impact
0.81

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Multi-target neuroprotection by dl-PHPB in APP/PS1 mice: a proteomic analysis

Guoliang Bai, Xian‐Fang Li, Yingni Sun, Yong Feng et al.
1 citations
Frontiers in Pharmacology
Signaling Pathways in Disease
0.81
article

Multi-target neuroprotection by dl-PHPB in APP/PS1 mice: a proteomic analysis

Guoliang Bai, Xian‐Fang Li, Yingni Sun, Yong Feng, Hong‐Mei Sun, Hongwei Gao, Kangmin Yang
article en
1 citations

Abstract

Our results revealed 11 altered proteins in the cortex and 10 in the hippocampus between the WT and APP/PS1 groups treated with vehicle. Following dl-PHPB treatment, 12 differentially expressed proteins were identified in the cortex and 9 in the hippocampus of APP/PS1 mice. These proteins are primarily involved in energy metabolism, neuronal structure, protein trafficking, inflammatory and oxidative responses, and amyloid β (Aβ) and Tau processes, among which several proteins were validated as potential therapeutic targets. Notably, the expression levels of cofilin-2 and VDAC1 in APP/PS1 mice were restored to near-normal levels by the treatment with dl-PHPB, memantine, or donepezil, and further clinical validation is required to establish their utility as AD biomarkers for therapeutic efficacy.

Frontiers in PharmacologyVol. 16
Binzhou Medical University (CN), Shandong University of Aeronautics (CN), Ludong University (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), University of Zurich (CH), National Institutes of Pharmaceutical Research and Development (China) (CN), Beijing Children’s Hospital (CN)
National Science Foundation, National Natural Science Foundation of China, China Postdoctoral Science Foundation, Natural Science Foundation of Shandong Province
Openalex Percentile: Top 29%
Signaling Pathways in Disease
0.81
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.