European survey on CAR T-Cell analytical methods from apheresis to post-infusion immunomonitoring
The survey underscored the necessity to standardize CAR T-cell functional potency assays and identify predictive biomarkers for response, relapse, and toxicity. Additionally, responses indicated significant variability in CAR T-cell monitoring during short-term patient follow-up across clinical centers. This European survey represents the first initiative to report current approaches in different stages of CAR T-cell therapies via a survey, from drug product quality controls to post-infusion immunomonitoring. Based on these findings, and with input from T2EVOLVE experts, the next step will be to address harmonization in the identified areas. These efforts are anticipated to significantly enhance cancer patients' access to engineered T cell therapy safely and effectively throughout Europe.
Authors
- Juan R. Rodríguez-Madoz (ORCID: https://orcid.org/0000-0003-4327-1866)
- Yolanda Cabrerizo
- Anne Galy (ORCID: https://orcid.org/0000-0002-0153-4392)
- Kerstin Neininger (ORCID: https://orcid.org/0000-0002-6177-8516)
- Julio Delgado (ORCID: https://orcid.org/0000-0002-5157-4376)
- Charis Girvalaki (ORCID: https://orcid.org/0000-0001-6849-0972)
- Franco Locatelli (ORCID: https://orcid.org/0000-0002-7976-3654)
- Andreas Kremer (ORCID: https://orcid.org/0000-0003-1466-0600)
- Biagio De Angelis (ORCID: https://orcid.org/0000-0002-7938-737X)
- Samir Chatterjee (ORCID: https://orcid.org/0000-0002-3268-6604)
- Anne Richter (ORCID: https://orcid.org/0000-0002-0598-5641)
- Concetta Quintarelli (ORCID: https://orcid.org/0000-0002-4343-9705)
- Maik Luu (ORCID: https://orcid.org/0000-0003-2843-3919)
- Maddalena Noviello (ORCID: https://orcid.org/0000-0002-3252-8876)
- Carmen Sanges (ORCID: https://orcid.org/0009-0000-1184-387X)
- Elena Tassi (ORCID: https://orcid.org/0000-0002-2921-8666)
- Paul Franz
- Michael Hudecek (ORCID: https://orcid.org/0000-0002-2280-2202)
- Hélène Negre
- Pacôme Lecot
- Elise Courcault
- Margot Lorrain
- L. Gambotti
- Caroline Dreuillet
- Maria Luisa D'Amore (ORCID: https://orcid.org/0000-0003-3488-4695)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Miltenyi Biotec (Germany) (DE)
- Vita-Salute San Raffaele University (IT)
- Inserm (FR)
- European CanCer Organisation (BE)
- European Hematology Association (NL)
- Institut des Neurosciences Paris-Saclay (FR)
- Centre Hospitalier Sud Francilien (FR)
- Bambino Gesù Children's Hospital (IT)
- Universitätsklinikum Würzburg (DE)
- Takeda (United States) (US)
- Fraunhofer Institute for Cell Therapy and Immunology (DE)
- Institut National du Cancer (FR)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Arbed (Luxembourg) (LU)
- University of Naples Federico II (IT)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1567582
- Citations
- 4
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 4.18