Bioactive natural alkaloid 6−Methoxydihydrosanguinarine exerts anti−tumor effects in hepatocellular carcinoma cells via ferroptosis
These findings reveal that the natural product 6-ME exerts anti-tumor functions in HCC cells <i>via</i> ferroptosis and underscore the potential of 6-ME administered alone or in combination with canonical ferroptosis inducers for the treatment of HCC patients.
Authors
- Liangjie Chen
- Xiaorui Jin
- Xueli Bian (ORCID: https://orcid.org/0000-0001-9940-8396)
- Linfen Han
- Donglin Li (ORCID: https://orcid.org/0000-0002-4221-8564)
- Yingping Li (ORCID: https://orcid.org/0000-0003-4145-8395)
- Chengchang Gao
- Qinqin Deng
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Shanxi Academy of Building Research (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-24
- DOI
- https://doi.org/10.3389/fphar.2025.1500461
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Natural Science Foundation of China