Microphysiological gut-on-chip enables extended in vitro development of Cryptosporidium hominis
These data demonstrate that bioengineered gut-on-chip models support extended <i>C. hominis</i> growth and can be used to interrogate responses of host cells to infection. Owing to its relative simplicity, the pumpless and tubeless gut-on-chip can be accessible to most laboratories with established HCT-8 infection models for <i>Cryptosporidium</i> culture.
Authors
- Samantha Gunasekera (ORCID: https://orcid.org/0000-0002-4262-4992)
- B. King (ORCID: https://orcid.org/0000-0002-6114-0950)
- Edward Cheah (ORCID: https://orcid.org/0000-0003-0962-0401)
- Nawal Hijjawi (ORCID: https://orcid.org/0000-0003-2489-5526)
- Peta L. Clode (ORCID: https://orcid.org/0000-0002-5188-4737)
- Mark O’Dea (ORCID: https://orcid.org/0000-0002-2757-7585)
- Jillian M. Carr (ORCID: https://orcid.org/0000-0002-1080-1472)
- Una Ryan (ORCID: https://orcid.org/0000-0003-2710-9324)
- Abha Chopra (ORCID: https://orcid.org/0000-0001-5008-9080)
- Mark Watson (ORCID: https://orcid.org/0000-0002-6438-9225)
- Paul Monis (ORCID: https://orcid.org/0000-0002-9052-4742)
- Benjamin Thierry (ORCID: https://orcid.org/0000-0002-6757-2842)
- Ramesh Ram (ORCID: https://orcid.org/0000-0002-4827-4778)
Institutions
- Hashemite University (JO)
- Flinders University (AU)
- University of South Australia (AU)
- Murdoch University (AU)
- The University of Western Australia (AU)
- South Australian Water Corporation (AU)
- Australian Water Quality Centre (AU)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-04-24
- DOI
- https://doi.org/10.3389/fcimb.2025.1564806
- Primary Topic
- Parasitic Infections and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Australian Government
- Melbourne Water