HIV-Tat upregulates the expression of senescence biomarkers in CD4+ T-cells
Intracellular, full-length HIV-Tat expression increases several senescence biomarkers in Jurkat and CD4<sup>+</sup> T-cells, and SASP/Aging mediators in cell supernatants. Intracellular HIV-Tat may initiate a cellular senescence program, contributing to the premature aging phenotype observed in PWH.
Authors
- Víctor Casanova (ORCID: https://orcid.org/0000-0002-4917-260X)
- Núria Climent (ORCID: https://orcid.org/0000-0002-0791-656X)
- Elisa Moraga (ORCID: https://orcid.org/0000-0001-5913-364X)
- Sonsoles Sánchez‐Palomino
- Josep Mallolas (ORCID: https://orcid.org/0000-0002-8365-141X)
- José María Miró (ORCID: https://orcid.org/0000-0001-8057-7755)
- José Alcamı́ (ORCID: https://orcid.org/0000-0003-0023-7377)
- Andrea Rodríguez-Agustín
- Rubén Ayala-Suárez (ORCID: https://orcid.org/0000-0002-1271-6466)
- Estebán Martínez (ORCID: https://orcid.org/0000-0002-6911-8846)
- María José Maleno (ORCID: https://orcid.org/0000-0002-7882-9973)
Institutions
- Real Academia Española (ES)
- Instituto de Salud Carlos III (ES)
- Centro Nacional de Microbiologia (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Clínic de Barcelona (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1568762
- Citations
- 4
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Universitat de Barcelona
- Instituto de Salud Carlos III