Potent antimicrobial activity of hydrogel loaded with the antimicrobial peptide, D-Bac8c2,5 Leu, against monospecies and polymicrobial biofilms of Staphylococcus aureus and Pseudomonas aeruginosa
These findings highlight the potential of D-Bac8c<sup>2,5 Leu</sup> to help address the urgent need for effective therapies against AMR pathogens and biofilm-associated wound infections. Further studies should focus on <i>in vivo</i> efficacy to optimize its therapeutic application in wound care.
Authors
- Deirdre Fitzgerald‐Hughes (ORCID: https://orcid.org/0000-0002-4843-3839)
- James P. O’Gara (ORCID: https://orcid.org/0000-0003-3866-7161)
- Lucas Sheridan (ORCID: https://orcid.org/0000-0001-8968-9630)
- Hawraa Shahrour (ORCID: https://orcid.org/0000-0002-4787-8262)
- Eoghan O’Neill (ORCID: https://orcid.org/0000-0001-5222-8339)
- Marc Devocelle (ORCID: https://orcid.org/0000-0001-7641-1306)
- Daniela Alves Ferreira (ORCID: https://orcid.org/0000-0003-0447-7773)
- H. William Kelly
Institutions
- Ollscoil na Gaillimhe – University of Galway (IE)
- Connolly Hospital Blanchardstown (IE)
- Beaumont Hospital (IE)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-04-24
- DOI
- https://doi.org/10.3389/fmicb.2025.1571649
- Citations
- 4
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 4.73
Funders
- Trinity College Dublin
- Cardiff Metropolitan University