Halogen Bonding Promoted Photoinduced Synthesis of 3,3-Disubstituted Oxindoles
A photoinduced and catalyst-free radical cyclization process for the synthesis of 3,3-disubstituted oxindoles is reported. This method utilizes readily available α-bromoanilides as substrates, showcasing a broad substrate scope. The reaction mechanism is facilitated by a photoactivated charge transfer complex based on the halogen bonding of α-bromoanilide with TMG and alcohol.
Authors
- Kun‐Quan Chen (ORCID: https://orcid.org/0000-0003-1898-4434)
- Xiaobo Chen
- Dequn Sun
- Jia Zhang
Institutions
- Southwest University of Science and Technology (CN)
- Putian University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1021/acs.joc.4c02963
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Putian University