Differential effects of aging, Alzheimer's pathology, and APOE4 on longitudinal functional connectivity and episodic memory in older adults
Our findings suggest differential effects of aging and AD pathology. Hypoconnectivity within PMC was related to aging and cognitive decline. MTL-PMC hyperconnectivity was related to early AD pathology and cognitive decline in APOE4 carriers. Future studies should investigate more diverse samples, nonetheless, our approach allowed us to identify longitudinal functional changes related to aging and early AD pathology, enhancing cross-sectional research. Hyperconnectivity has been proposed as a mechanism related to early AD pathology before, we now contribute specific functional connections to focus on in future research.
Authors
- Jennifer Tremblay‐Mercier (ORCID: https://orcid.org/0000-0001-5824-3740)
- Alexa Pichet Binette (ORCID: https://orcid.org/0000-0001-5218-3337)
- Jordana Remz
- Anne Maaß (ORCID: https://orcid.org/0000-0002-7889-795X)
- Niklas Vockert (ORCID: https://orcid.org/0000-0001-5915-2517)
- Larissa Fischer (ORCID: https://orcid.org/0009-0001-9936-2954)
- Jenna N. Adams (ORCID: https://orcid.org/0000-0002-6702-3851)
- Sylvia Villeneuve (ORCID: https://orcid.org/0000-0003-2338-0467)
- Eóin N. Molloy (ORCID: https://orcid.org/0000-0002-7804-2214)
Institutions
- Lund University (SE)
- University of California, Irvine (US)
- Douglas Mental Health University Institute (CA)
- German Center for Neurodegenerative Diseases (DE)
- Institut Universitaire de Gériatrie de Montréal (CA)
- McGill University (CA)
- Université de Montréal (CA)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1186/s13195-025-01742-6
- Citations
- 10
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 14.31
Funders
- Deutsche Forschungsgemeinschaft
- Otto von Guericke University Magdeburg