Dolutegravir/Abacavir/Lamivudine in Acute HIV-1 Results in Rapid Suppression and Restoration of CD4 T-cell Subsets Without Accelerated Decay of Latent HIV-1
Integrase-based ART during acute HIV-1 resulted in brisk viral suppression, preservation of CD4+ T-cell subsets, and decline in resting CD4+ T-cell infection.
Authors
- David M. Margolis (ORCID: https://orcid.org/0000-0001-5714-0002)
- Mehri S. McKellar (ORCID: https://orcid.org/0000-0003-2942-5398)
- JoAnn Kuruc (ORCID: https://orcid.org/0000-0001-8874-8950)
- Kara McGee (ORCID: https://orcid.org/0000-0003-1560-8820)
- Joseph J. Eron (ORCID: https://orcid.org/0000-0002-4938-0644)
- Nancie M. Archin (ORCID: https://orcid.org/0000-0002-7938-0389)
- Eric T. Weimer (ORCID: https://orcid.org/0000-0003-3677-5724)
- John L. Schmitz (ORCID: https://orcid.org/0000-0002-1425-236X)
- Cynthia L. Gay (ORCID: https://orcid.org/0000-0002-3620-3059)
- Nilu Goonetilleke (ORCID: https://orcid.org/0000-0003-2278-1656)
- Alexis Sponaugle (ORCID: https://orcid.org/0000-0002-5722-3470)
- Jessica Keys (ORCID: https://orcid.org/0000-0001-5093-378X)
- Chelston Ang
- Caroline Baker
Institutions
- University of North Carolina at Chapel Hill (US)
- Duke University (US)
- North Central State College (US)
- UNC/NCSU Joint Department of Biomedical Engineering (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1093/ofid/ofaf247
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- North Carolina Department of Health and Human Services