Chaperone-mediated autophagy sustains pericyte stemness necessary for brain tissue homeostasis
we show that manipulation of CMA activity in host PCs could be a useful therapeutical approach in the context of brain inflammation, which might be extended to other diseases where the pericyte has a key role in response to inflammation.
Authors
- Juan R. Rodríguez-Madoz (ORCID: https://orcid.org/0000-0003-4327-1866)
- M. Salinas (ORCID: https://orcid.org/0000-0002-5859-0969)
- Felipe Prósper (ORCID: https://orcid.org/0000-0001-6115-8790)
- Francisco J. Roca (ORCID: https://orcid.org/0000-0002-6744-148X)
- A. Zapata (ORCID: https://orcid.org/0000-0003-0576-2672)
- Marta Martínez-Morga
- Rut Valdor (ORCID: https://orcid.org/0000-0002-2681-0779)
- David García‐Bernal (ORCID: https://orcid.org/0000-0001-6610-8442)
- José M. Moraleda (ORCID: https://orcid.org/0000-0001-9080-1466)
- Carlos Martínez (ORCID: https://orcid.org/0000-0003-3307-1326)
- Salvador Martı́nez (ORCID: https://orcid.org/0000-0002-9320-4103)
Institutions
- Universidad Complutense de Madrid (ES)
- Instituto de Neurociencias (ES)
- Clinica Universidad de Navarra (ES)
- Instituto Murciano de Investigación Biosanitaria (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Universidad de Murcia (ES)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1016/j.jare.2025.04.015
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00