Case Series of Patients With Laboratory-Confirmed Marburg Virus Disease in 2023 in Equatorial Guinea
Contrary to some reports and the recommended case definition for MVD, our patients presented with a rash but did not exhibit vomiting or diarrhea. Hemorrhagic signs were solely observed in the terminal stage, preceding demise. Despite the limited sample size, these findings emphasize the importance of tailoring the case definition to the specific outbreak. Further evidence on the efficacy and safety of therapeutics for MVD, including remdesivir, should be gathered through well-designed trials during future epidemic responses.
Authors
- Stephen R. Welch (ORCID: https://orcid.org/0000-0002-6905-8521)
- Olivier le Polain de Waroux (ORCID: https://orcid.org/0000-0003-3458-2945)
- Oren Mayer
- Richard Kojan (ORCID: https://orcid.org/0000-0003-3415-2830)
- John D. Klena (ORCID: https://orcid.org/0000-0001-9933-6193)
- Ruggero Giuliani (ORCID: https://orcid.org/0000-0002-8282-2694)
- Antoine Chaillon (ORCID: https://orcid.org/0000-0001-9490-3857)
- Mary J. Choi (ORCID: https://orcid.org/0000-0001-9373-2355)
- María E. Negrón (ORCID: https://orcid.org/0000-0001-5238-6847)
- Emily Zielinski Gutiérrez
- Anaïs Legand
- Florine E. M. Scholte (ORCID: https://orcid.org/0000-0003-2110-3087)
- Frédérique Jacquérioz (ORCID: https://orcid.org/0000-0002-6957-0920)
- Janet Dı́az (ORCID: https://orcid.org/0000-0002-8753-531X)
- Stephanie Ngai (ORCID: https://orcid.org/0000-0003-4699-1332)
- Pierre Formenty (ORCID: https://orcid.org/0000-0002-9482-5411)
- Michele Di Marco (ORCID: https://orcid.org/0009-0009-5407-7576)
- Hans-Joerg Lang (ORCID: https://orcid.org/0000-0001-6452-5381)
- Anna Silenzi (ORCID: https://orcid.org/0000-0002-3893-8171)
- Florentino Abaga Ondo Ndoho
- Luca Fontana (ORCID: https://orcid.org/0000-0002-8614-4114)
- Candido Ondo Ondo Avomo (ORCID: https://orcid.org/0009-0007-3087-4517)
- Ladislao Ekiri Ngomo Mikue (ORCID: https://orcid.org/0009-0005-4396-1957)
- Domitila Ñadang Fuga Eyemam (ORCID: https://orcid.org/0009-0003-1081-1157)
- Micaela Ayang Nguere
- Ilda Elobe Mometolo
- Rosalia Nazang Bibang Nzang
- Damaso Mitogo Nguema Maye
- Yiliam Fundora Suarez
- Salvador Eduardo Esono
- José Antonio Miko Ayang
Institutions
- Centers for Disease Control and Prevention (US)
- World Health Organization - Pakistan (PK)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Alliance for International Medical Action (SN)
- Hôpital Beau-Séjour (CH)
- Centers for Disease Control and Prevention (UG)
- World Health Organization (CH)
- Ministerio de Salud Pública (EC)
- Ministerio de Salud (BO)
- Azienda Socio Sanitaria Territoriale Lariana (IT)
- Ministerio de Salud Pública y Bienestar Social (PY)
- George Institute for Global Health (IN)
- Centers for Disease Control and Prevention (KE)
- National University of Equatorial Guinea (GQ)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1093/cid/ciaf208
- Primary Topic
- Viral Infections and Outbreaks Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00