Methane Valorization to Antioxidant Polysaccharides by Methanotrophic Bacteria
Bioconversion of methane into functional polysaccharides presents a promising strategy for mitigating methane-induced greenhouse gas emissions and addressing the limitations of plant-derived polysaccharide and sugar-based microbial polysaccharides production. In this study, the novel methane-derived polysaccharide (MePS) was obtained from a newly isolated methanotrophic bacterium <i>Alkalicoccus glycogenes</i> WONF2802. Structural characterization found that MePS is a branched-chain glucan with a weight-average molecular weight of 283.2 kDa. Additionally, MePS exhibited considerable antioxidant capacities in both <i>in vitro</i> biochemical assays and the H<sub>2</sub>O<sub>2</sub>-induced oxidative stress cell model. This work establishes a potential pathway for polysaccharide production, reducing reliance on plant and sugar-based feedstocks, while offering a new strategy for methane emission reduction.
Authors
- Rongzhan Fu (ORCID: https://orcid.org/0000-0003-1517-6431)
- Heng Yin (ORCID: https://orcid.org/0000-0001-8193-9236)
- Liang Shi (ORCID: https://orcid.org/0000-0003-4546-4741)
- Daidi Fan (ORCID: https://orcid.org/0000-0001-9798-1674)
- Zixi Gao (ORCID: https://orcid.org/0000-0002-1410-7648)
- Yuan Liu (ORCID: https://orcid.org/0000-0001-5409-8064)
- Qiang Fei (ORCID: https://orcid.org/0000-0002-6716-649X)
- Hui Gu (ORCID: https://orcid.org/0000-0001-8312-9536)
- Chao An (ORCID: https://orcid.org/0000-0002-3254-6871)
- Shen Li
- Wenjiao Xue (ORCID: https://orcid.org/0000-0002-8867-1575)
Institutions
- Xidian University (CN)
- Dalian Institute of Chemical Physics (CN)
- Biocon (Switzerland) (CH)
- Chinese Academy of Sciences (CN)
- Czech Academy of Sciences, Institute of Microbiology (CZ)
- Microbiology Institute of Shaanxi (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Journal of Agricultural and Food Chemistry
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1021/acs.jafc.5c01087
- Citations
- 2
- Primary Topic
- Microbial metabolism and enzyme function
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Shaanxi Provincial Science and Technology Department
- Higher Education Discipline Innovation Project