Low blood levels of selenium, selenoprotein P and GPx3 are associated with accelerated biological aging: results from the Berlin Aging Study II (BASE-II)
Our study suggests that low levels of selenium biomarkers are associated with accelerated biological aging measured through epigenetic clocks. This effect was not substantially changed after adjustment for known confounders.
Authors
- Christina M. Lill (ORCID: https://orcid.org/0000-0002-2805-1307)
- Lars Bertram (ORCID: https://orcid.org/0000-0002-0108-124X)
- Thilo Samson Chillon (ORCID: https://orcid.org/0000-0001-7706-7906)
- Elisabeth Steinhagen‐Thiessen (ORCID: https://orcid.org/0000-0003-3056-3317)
- Lutz Schomburg (ORCID: https://orcid.org/0000-0001-9445-1555)
- Orr Shomroni (ORCID: https://orcid.org/0000-0002-8009-2392)
- Kamil Demircan (ORCID: https://orcid.org/0000-0003-2256-7019)
- Valentin Max Vetter (ORCID: https://orcid.org/0000-0001-5003-7766)
- Jan Homann (ORCID: https://orcid.org/0000-0003-2791-7065)
- Michael Mülleder (ORCID: https://orcid.org/0000-0001-9792-3861)
- Markus Ralser (ORCID: https://orcid.org/0000-0001-9535-7413)
- Ilja Demuth (ORCID: https://orcid.org/0000-0002-4340-2523)
Institutions
- Centre for Human Genetics (GB)
- University of Münster (DE)
- Nuffield Orthopaedic Centre (GB)
- Humboldt-Universität zu Berlin (DE)
- University of Oxford (GB)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Imperial College London (GB)
- University of Lübeck (DE)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1186/s13148-025-01863-7
- Citations
- 8
- Primary Topic
- Selenium in Biological Systems
- Type
- article
- Field-Weighted Citation Impact
- 8.96
Funders
- Cure Alzheimer's Fund
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Charité – Universitätsmedizin Berlin
- Deutschen Konsortium für Translationale Krebsforschung
- Berlin University Alliance
- European Research Council