White matter hyperintensities and relapse risk in late-life depression
Our results show that WMH burden may play a role in the early - but not the delayed - relapse of LLD, and they underscore the intricate dynamic of the biological markers underlying LLD treatment response and relapse.
Authors
- Helmet T. Karim (ORCID: https://orcid.org/0000-0002-9286-0694)
- Warren D. Taylor (ORCID: https://orcid.org/0000-0002-9975-3082)
- Robert T. Krafty (ORCID: https://orcid.org/0000-0003-1478-6430)
- Leigh B. Pearcy (ORCID: https://orcid.org/0000-0002-4864-2446)
- Sarah M. Szymkowicz (ORCID: https://orcid.org/0000-0001-5333-7211)
- Brian D. Boyd (ORCID: https://orcid.org/0000-0002-2055-8154)
- Bennett A. Landman (ORCID: https://orcid.org/0000-0001-5733-2127)
- Layla Banihashemi (ORCID: https://orcid.org/0000-0001-6317-0494)
- Meryl A. Butters (ORCID: https://orcid.org/0000-0002-2563-817X)
- Olusola Ajilore (ORCID: https://orcid.org/0000-0003-0737-0437)
- Carmen Andreescu (ORCID: https://orcid.org/0000-0003-3767-5127)
Institutions
- Emory University (US)
- University of Pittsburgh (US)
- University of Illinois Chicago (US)
- UPMC Health System (US)
- VA Tennessee Valley Healthcare System (US)
- University of Pittsburgh Medical Center (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1016/j.jad.2025.04.116
- Citations
- 7
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 10.30
Funders
- National Institutes of Health
- National Institute of Mental Health
- National Center for Advancing Translational Sciences