Accuracy and Prognosis of Extranodal Extension on Radiologic Imaging in Human Papillomavirus-Mediated Oropharyngeal Cancer: A Head and Neck Cancer International Group (HNCIG) Real-world Study
In current real-world practice, iENE showed widely varying and modest accuracy, and was not independently prognostic of outcomes in HPV + OPC. iENE accuracy and prognostic power increased significantly by using combined CT and MRI scanning, experienced head and neck radiologists and more inclusive diagnostic criteria. Validated consensus diagnostic criteria and protocols are urgently needed to enhance the clinical utility of iENE. Until then, clinicians should be cautious about making treatment decisions based on iENE.
Authors
- Ahmad K. Abou‐Foul (ORCID: https://orcid.org/0000-0002-5321-5465)
- Lachlan McDowell (ORCID: https://orcid.org/0000-0002-4268-3079)
- Caroline Kristunas (ORCID: https://orcid.org/0000-0001-8945-4671)
- Kathrine Kronberg Jakobsen (ORCID: https://orcid.org/0000-0003-0336-5411)
- Zsuzsanna Iyizoba-Ebozue (ORCID: https://orcid.org/0000-0002-9839-4532)
- Irene H. Nauta (ORCID: https://orcid.org/0000-0003-0318-715X)
- Jacob H. Rasmussen (ORCID: https://orcid.org/0000-0003-1494-3352)
- Christina Henson (ORCID: https://orcid.org/0000-0002-5419-4125)
- Benedikt Schmidl (ORCID: https://orcid.org/0000-0003-2201-4246)
- Christian Grønhøj (ORCID: https://orcid.org/0000-0002-4524-8291)
- P. K. R. Nair (ORCID: https://orcid.org/0000-0002-9889-2275)
- Professor Jens Peter Klussmann
- Paul Nankivell (ORCID: https://orcid.org/0000-0003-4664-6117)
- Marc Oliva (ORCID: https://orcid.org/0000-0001-5352-8130)
- Martina A. Broglie (ORCID: https://orcid.org/0000-0002-5573-818X)
- Mantegh Sethi (ORCID: https://orcid.org/0000-0001-5270-848X)
- Daniel R. Awad (ORCID: https://orcid.org/0000-0003-0121-6930)
- Dr Muaz Hj Mohd Noor
- Vishal Gupta (ORCID: https://orcid.org/0000-0002-1518-6624)
- Jan Hendrickx (ORCID: https://orcid.org/0009-0000-9846-0408)
- Pengfei Zhao (ORCID: https://orcid.org/0000-0002-9210-6544)
- P. Krishnan
- Professor Hisham Mehanna
- Professor William M Lydiatt
- Professor Barton F Branstetter
- Professor Barbara Wollenberg
- Professor Robin Prestwich
- Dr Anne-Laure Gaultier
- Professor Sue S Yom
- Professor C René Leemans
- Professor Michiel Wm van-den-Brekel
- Professor Christian von-Buchwald
Institutions
- Creighton University (US)
- Houston Methodist (US)
- University of Leeds (GB)
- Royal Adelaide Hospital (AU)
- Mount Sinai Health System (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- Université Paris Cité (FR)
- Tata Memorial Hospital (IN)
- Nebraska Methodist College (US)
- Princess Alexandra Hospital (AU)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- The Netherlands Cancer Institute (NL)
- UNSW Sydney (AU)
- Women's Hospital (US)
- University Hospital of Zurich (CH)
- Hôpital Européen Georges-Pompidou (FR)
- Institut Català d'Oncologia (ES)
- Hôpital Européen (FR)
- Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NL)
- Methodist Hospital (US)
- Oklahoma State University Oklahoma City (US)
- University Hospital Cologne (DE)
- University of Oklahoma Health Sciences Center (US)
- Technical University of Munich (DE)
- University of Birmingham (GB)
- University of Amsterdam (NL)
Publication Details
- Journal
- International Journal of Radiation Oncology*Biology*Physics
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1016/j.ijrobp.2025.04.003
- Citations
- 3
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.54
Funders
- Bristol-Myers Squibb
- AstraZeneca
- Sanofi
- Gilead Sciences
- Seagen
- EMD Serono
- Sanofi Pasteur