CH25H/25-HC promotes pulmonary fibrosis via AMPK/STAT6 pathway-dependent M2 macrophage polarization in COPD
Our findings demonstrate that CH25H/25-HC exacerbates COPD-associated pulmonary fibrosis by promoting AMPK/STAT6-dependent M2 macrophage polarization. Targeting CH25H may represent a novel therapeutic strategy for mitigating fibrosis in COPD.
Authors
- Minghao Yin (ORCID: https://orcid.org/0000-0002-6226-2394)
- Yadan Li (ORCID: https://orcid.org/0000-0003-4825-7887)
- Guangzhi Xiao
- Fengfan Yang
- Zhaohui Zheng
- Xing Luo (ORCID: https://orcid.org/0000-0001-7358-3196)
Institutions
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Immunobiology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1016/j.imbio.2025.152908
- Citations
- 3
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Natural Science Basic Research Program of Shaanxi Province