Dihydroartemisinin ameliorates hemarthrosis-induced cartilage degeneration by suppressing chondrocyte senescence via activation of Keap1-Nrf2 signaling pathway
On the one hand, this study highlights the important role of chondrocyte senescence in hemarthrosis-induced cartilage degradation, implying that inhibiting chondrocyte senescence may be a viable therapeutic strategy for blood-induced arthropathy. On the other hand, our findings demonstrate the remarkable chondroprotective effect of DHA in bleeding joint by modulating the Nrf2/Keap1 anti-oxidative signaling pathway, suggesting DHA may serve as a potential candidate drug for the therapy of blood-induced arthropathy.
Authors
- Kaiao Zou (ORCID: https://orcid.org/0009-0006-5047-6922)
- Pinger Wang (ORCID: https://orcid.org/0000-0002-4124-0188)
- Hongting Jin
- Yuliang Huang (ORCID: https://orcid.org/0000-0001-9994-472X)
- Haipeng Huang (ORCID: https://orcid.org/0000-0001-5375-7558)
- Peijian Tong (ORCID: https://orcid.org/0000-0003-0948-8674)
- Qinghe Zeng (ORCID: https://orcid.org/0000-0001-7543-0329)
- Jiali Chen (ORCID: https://orcid.org/0009-0009-9876-6103)
- Xuefeng Li (ORCID: https://orcid.org/0000-0001-8146-8374)
- Weidong Wang (ORCID: https://orcid.org/0000-0003-2523-3145)
- Yongjia Feng
- Wenhua Yuan (ORCID: https://orcid.org/0000-0002-4126-821X)
- Wenzhe Chen (ORCID: https://orcid.org/0000-0003-4412-1851)
Institutions
- Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1016/j.jot.2025.04.006
- Citations
- 1
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.67