Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement
Together our findings highlighted widespread transcriptome alterations in ALS post-mortem brain and showed that, despite the absence of pTDP-43 pathology in the cerebellum, extensive and pTDP-43 pathological stage-specific RNA changes are evident in this brain region.
Authors
- Claire E. Shepherd (ORCID: https://orcid.org/0000-0002-0399-3218)
- Dominic B. Rowe (ORCID: https://orcid.org/0000-0003-0912-2146)
- Kelly L. Williams (ORCID: https://orcid.org/0000-0001-6319-9473)
- Luke Carroll (ORCID: https://orcid.org/0000-0002-8600-4023)
- Ian P. Blair (ORCID: https://orcid.org/0000-0003-3083-0075)
- Natalie Grima (ORCID: https://orcid.org/0000-0001-6434-7706)
- Matthew C. Kiernan (ORCID: https://orcid.org/0000-0001-9054-026X)
- Lyndal Henden (ORCID: https://orcid.org/0000-0001-5541-7637)
- Andrew Smith (ORCID: https://orcid.org/0000-0002-9169-9202)
- Thiri Zaw
Institutions
- The University of Sydney (AU)
- Royal Prince Alfred Hospital (AU)
- AGRF Ltd (AU)
- Neuroscience Research Australia (AU)
- Macquarie University (AU)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1186/s13024-025-00820-5
- Citations
- 9
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 12.50
Funders
- Neuroscience Research Australia
- FightMND
- Motor Neurone Disease Research Australia
- National Institutes of Health
- National Health and Medical Research Council
- National Institute on Alcohol Abuse and Alcoholism