Diazoxide as a bridging therapy in methadone-induced hypoglycemia– a case report and review of the literature
While diazoxide has been used as bridging therapy for insulinoma patients awaiting surgery, this report highlights the utility of the non-diuretic benzothiadiazine in opioid-induced hyperinsulinemic hypoglycemia. Patients with hyperinsulinemic hypoglycemia on high doses of tramadol or methadone should be transitioned off the offending agent; however, diazoxide is an effective, alternative option when the transition is not feasible or needs to be delayed.
Authors
- Shiv Shankar Sinha (ORCID: https://orcid.org/0009-0009-0703-6288)
- Katherine I. Wolf (ORCID: https://orcid.org/0000-0001-8540-8248)
- Shafaq Khairi
- Eric D. Buras (ORCID: https://orcid.org/0000-0002-7679-2484)
Institutions
- Michigan Medicine (US)
Publication Details
- Journal
- Cardiovascular Diabetology – Endocrinology Reports
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1186/s40842-025-00220-0
- Citations
- 2
- Primary Topic
- Pain Management and Opioid Use
- Type
- article
- Field-Weighted Citation Impact
- 4.38
Funders
- National Heart, Lung, and Blood Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- Michigan Nutrition Obesity Research Center, Medical School, University of Michigan