Ambient fine particulate matter induces cardiac fibrosis through triggering ferroptosis by heme degradation induced-iron overload
Collectively, our study showed that the activation of ferroptosis/TGF-β1/Smad3 signaling pathway, initiated by heme degradation-induced iron overload in cardiomyocytes, serves as a mechanism in murine models of PM<sub>2.5</sub>-induced cardiac fibrosis.
Authors
- Shibin Ding (ORCID: https://orcid.org/0000-0003-1341-3595)
- Qin Wu (ORCID: https://orcid.org/0000-0002-9519-7269)
- Jinjin Jiang
- Yuping Chen (ORCID: https://orcid.org/0000-0001-8562-0804)
- Li Yang (ORCID: https://orcid.org/0000-0002-7432-8178)
Institutions
- Jiangsu Vocational College of Medicine (CN)
- Jiangsu Provincial Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1016/j.ecoenv.2025.118227
- Citations
- 2
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 2.40