Regioselective Formal (3+2) Cyclization of Propargylic para-Quinone Methides (p-QMs) with β-Keto Carbonyls: Direct Access to (Fused)-Furans
Abstract We report a calcium(II)-catalyzed, base-promoted, formal (3+2) cyclization of para-quinone methides with 1,3-dicarbonyl derivatives to access furans, dihydrofurans, dihydrobenzofurans, and naphthofurans under solvent-free conditions. The reaction shows good substrate generality and excellent regioselectivity.
Authors
- Srinivasarao Yaragorla (ORCID: https://orcid.org/0000-0001-6152-5861)
- Liyaqat Ali (ORCID: https://orcid.org/0000-0003-0523-1521)
- Avinash Kumar (ORCID: https://orcid.org/0000-0002-8148-9252)
Publication Details
- Journal
- Synlett
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1055/s-0043-1773538
- Primary Topic
- Synthesis of Indole Derivatives
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Hyderabad