Specific MSI2 deletion maintains intestinal barrier integrity by down-regulating ILC3s-derived IL-17 a in mice with colitis
Specific deletion of MSI2 alleviates DSS-induced colitis in mice by reducing ILC3s infiltration and IL-17 A secretion in the lamina propria of the colon. This decrease in inflammatory mediators and cell infiltration dampens the inflammatory response in the intestinal mucosa, helping to maintain the integrity of the intestinal barrier in mice with colitis. These findings enhance our understanding of UC pathogenesis and offer novel avenues for clinical diagnosis and treatment.
Authors
- Nengneng Li
- Zeyang Lin
- Xia Wu (ORCID: https://orcid.org/0000-0002-0024-4481)
- Guohong Zhuang (ORCID: https://orcid.org/0000-0001-9653-627X)
- Peizhen Wen
- Shuaishuai Zhang (ORCID: https://orcid.org/0000-0002-1441-4840)
- Changxiu Yan (ORCID: https://orcid.org/0000-0001-8504-0199)
- Yunyun Qian
- Yi Xiao (ORCID: https://orcid.org/0000-0001-5315-7771)
- Qiang Zhu (ORCID: https://orcid.org/0000-0002-2405-6776)
- Kun Zhang (ORCID: https://orcid.org/0000-0002-8916-556X)
- Jie Ma (ORCID: https://orcid.org/0000-0002-5729-1297)
- Shiying Zhang
- Jianfa Zhong
Institutions
- Fujian Medical University (CN)
- Xiamen University (CN)
- Shanghai Changzheng Hospital (CN)
- Fuzhou General Hospital of Nanjing Military Command (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Xiamen University of Technology (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1016/j.intimp.2025.114717
- Citations
- 1
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.80