Balanced Steady-State Free Precession Enables High-Resolution Dynamic 3D Deuterium Metabolic Imaging of the Human Brain at 7T
In this study we successfully implemented a balanced steady-state free precession (bSSFP) acquisition scheme for dynamic whole-brain human DMI at 7T. A 3-fold SNR increase compared to conventional spoiled acquisition allowed us to double the spatial resolution achieved using conventional FID-CRT DMI. Systemic continuous glucose measurements, combined with dynamic DMI, demonstrate significant potential for clinical applications. This could help improve our understanding of brain glucose metabolism by linking it to time-resolved peripheral glucose levels. Importantly, these measurements are conducted in a minimally invasive and physiological manner.
Authors
- Martin Krššák (ORCID: https://orcid.org/0000-0001-9717-803X)
- Rupert R. Lanzenberger (ORCID: https://orcid.org/0000-0003-4641-9539)
- Wolfgang Bogner (ORCID: https://orcid.org/0000-0002-0130-3463)
- Stanislav Motyka (ORCID: https://orcid.org/0000-0002-6314-316X)
- Lukas Hingerl (ORCID: https://orcid.org/0000-0003-1808-8349)
- Elton Tadeu Montrazi (ORCID: https://orcid.org/0000-0001-5898-1153)
- Fabian Niess (ORCID: https://orcid.org/0000-0003-1235-7595)
- Thomas Scherer (ORCID: https://orcid.org/0000-0003-4980-706X)
- Bernhard Strasser (ORCID: https://orcid.org/0000-0001-9542-3855)
- Lucio Frydman (ORCID: https://orcid.org/0000-0001-8208-3521)
- Anna Duguid (ORCID: https://orcid.org/0009-0003-7044-3165)
- Viola Bader (ORCID: https://orcid.org/0009-0004-2393-9579)
- S.D. Frese
- Aaron Osburg (ORCID: https://orcid.org/0009-0001-2622-3355)
Institutions
- Medical University of Vienna (AT)
Publication Details
- Journal
- Investigative Radiology
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1097/rli.0000000000001196
- Citations
- 4
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 5.44