Exploring predictive biomarkers of efficacy and survival with nivolumab treatment for unresectable/recurrent esophageal squamous cell carcinoma

CD8<sup>+</sup> and CCR8<sup>+</sup> cell counts, CD8/Foxp3 and CD8/CCR8 ratios, and TLS density may be predictive biomarkers of therapeutic efficacy and survival with PD-1 blockade for ESCC.

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Publication Details

Journal
Esophagus
Published
2025-04-24
DOI
https://doi.org/10.1007/s10388-025-01120-z
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
0.00

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article

Exploring predictive biomarkers of efficacy and survival with nivolumab treatment for unresectable/recurrent esophageal squamous cell carcinoma

Kotaro Yamashita, Yusuke Akamaru, Masaaki Motoori, Hiroshi Miyata et al.
Esophagus
Cancer Immunotherapy and Biomarkers
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Exploring predictive biomarkers of efficacy and survival with nivolumab treatment for unresectable/recurrent esophageal squamous cell carcinoma

Kotaro Yamashita, Yusuke Akamaru, Masaaki Motoori, Hiroshi Miyata, Yutaka Kimura, Hisashi Wada, Yuichiro� Doki, Shigeto Nakai, Azumi Ueyama, Yukinori Kurokawa, Sachiko Yamamoto, Eiichi Morii, Koji Tanaka, Ryohei Kawabata, Tomoki Makino, Hidetoshi Eguchi, Jin Matsuyama, Motohiro Hirao, Hitomi Morihara, Kota Momose
article en

Abstract

CD8<sup>+</sup> and CCR8<sup>+</sup> cell counts, CD8/Foxp3 and CD8/CCR8 ratios, and TLS density may be predictive biomarkers of therapeutic efficacy and survival with PD-1 blockade for ESCC.

EsophagusVol. 22(3)
Osaka Prefectural Medical Center (JP), Osaka National Hospital (JP), Osaka City General Hospital (JP), Sakai Municipal Hospital (JP), Osaka Rosai Hospital (JP), Osaka International Cancer Institute (JP), Kindai University (JP), The University of Osaka (JP)
Takeda Science Foundation, Japan Research Foundation for Clinical Pharmacology, Uehara Memorial Foundation, Kindai University, Kanazawa University, Princess Takamatsu Cancer Research Fund
Good health and well-being
Openalex Percentile: Top 87%
Cancer Immunotherapy and Biomarkers
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