Exploring predictive biomarkers of efficacy and survival with nivolumab treatment for unresectable/recurrent esophageal squamous cell carcinoma
CD8<sup>+</sup> and CCR8<sup>+</sup> cell counts, CD8/Foxp3 and CD8/CCR8 ratios, and TLS density may be predictive biomarkers of therapeutic efficacy and survival with PD-1 blockade for ESCC.
Authors
- Kotaro Yamashita (ORCID: https://orcid.org/0000-0001-9538-5705)
- Yusuke Akamaru
- Masaaki Motoori (ORCID: https://orcid.org/0000-0002-8529-2844)
- Hiroshi Miyata (ORCID: https://orcid.org/0000-0002-1062-9158)
- Yutaka Kimura (ORCID: https://orcid.org/0000-0002-1823-9234)
- Hisashi Wada (ORCID: https://orcid.org/0000-0002-5444-6193)
- Yuichiro� Doki (ORCID: https://orcid.org/0000-0001-7346-0209)
- Shigeto Nakai
- Azumi Ueyama (ORCID: https://orcid.org/0009-0007-1352-761X)
- Yukinori Kurokawa (ORCID: https://orcid.org/0000-0002-2883-0132)
- Sachiko Yamamoto (ORCID: https://orcid.org/0000-0003-2257-5270)
- Eiichi Morii (ORCID: https://orcid.org/0000-0001-8490-3650)
- Koji Tanaka (ORCID: https://orcid.org/0000-0002-7932-8601)
- Ryohei Kawabata (ORCID: https://orcid.org/0000-0001-7386-1096)
- Tomoki Makino (ORCID: https://orcid.org/0000-0001-7918-4217)
- Hidetoshi Eguchi (ORCID: https://orcid.org/0000-0002-2318-1129)
- Jin Matsuyama (ORCID: https://orcid.org/0000-0001-9060-282X)
- Motohiro Hirao (ORCID: https://orcid.org/0000-0002-6509-6416)
- Hitomi Morihara (ORCID: https://orcid.org/0009-0005-5799-1532)
- Kota Momose
Institutions
- Osaka Prefectural Medical Center (JP)
- Osaka National Hospital (JP)
- Osaka City General Hospital (JP)
- Sakai Municipal Hospital (JP)
- Osaka Rosai Hospital (JP)
- Osaka International Cancer Institute (JP)
- Kindai University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Esophagus
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1007/s10388-025-01120-z
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Takeda Science Foundation
- Japan Research Foundation for Clinical Pharmacology
- Uehara Memorial Foundation
- Kindai University
- Kanazawa University
- Princess Takamatsu Cancer Research Fund