Inhibition of P2Y2 Attenuates Cisplatin-Induced AKI via Reduced Oxidative Stress, Inflammation and Cell Death
Taken together, our study, for the first time revealed that P2Y2 plays an important role in CIA by regulating oxidative stress, inflammation, apoptosis, and necroptosis and its inhibitor, AR-C, is a potential drug for treating CIA.
Authors
- Weidong Cao (ORCID: https://orcid.org/0000-0001-5346-5571)
- Yang Du
- Songming Huang (ORCID: https://orcid.org/0000-0002-1293-0198)
- Fengyu Su (ORCID: https://orcid.org/0000-0003-1922-9182)
- Zhanjun Jia (ORCID: https://orcid.org/0000-0002-3107-0429)
- Xiaomei Tang (ORCID: https://orcid.org/0000-0001-5914-4373)
- Yue Zhang (ORCID: https://orcid.org/0009-0001-2552-7146)
- Anning Zhou (ORCID: https://orcid.org/0000-0003-3512-2756)
- Ting Wang (ORCID: https://orcid.org/0000-0001-8683-2956)
- Shuang Chen (ORCID: https://orcid.org/0000-0002-2919-4967)
- Aihua Zhang (ORCID: https://orcid.org/0000-0001-7438-4404)
- Xiuli Lin
- Yaqiong Shang
- Yan Guo (ORCID: https://orcid.org/0000-0002-2721-7846)
Institutions
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Kidney Diseases
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1159/000546033
- Citations
- 1
- Primary Topic
- Chemotherapy-induced organ toxicity mitigation
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Natural Science Foundation of China