Cognitive and neurophysiological effects of bilateral tDCS neuromodulation in patients with minimally conscious state

The minimally conscious state (MCS) is a clinical condition characterized by severely reduced but present awareness of self and the environment. Transcranial direct current stimulation (tDCS) has shown promising potential. The aim of this quasi-randomised control study was to investigate the effects of bilateral of tDCS applied to the right and left dorsolateral prefrontal cortex (DLPFC) on neurophysiological and cognitive outcomes in 28 patients with MCS. Participants were quasi-randomly assigned to one of two groups: experimental group with tDCS over both DLPFC, and a control group, which received sham tDCS. Neurophysiological assessments included event-related potentials (ERPs) analysis (N200 and P300) and EEG beta band study. Clinical outcomes were measured using ad hoc psychometric battery, including Coma Recovery Scale-Revised (CRS-R), Levels of Cognitive Functioning Scale (LCFS), and Functional Independence Measure (FIM). The findings revealed a significant improvement in ERP latencies and increased beta band rhythms in the experimental group, indicating enhanced neural responsiveness to cognitive stimuli. Additionally, significant improvements were observed in clinical measures of awareness and functional capacity. These findings suggest that tDCS may represent a promising therapeutic option for enhancing both neurophysiological responses and cognitive functioning in patients with MCS.