Expression of the TIGIT axis and the CD39/CD73 purinergic pathway in bone metastasis-derived immune cells
The study shows that an altered immune cell composition is present in BM across the different tumor entities. Additionally, molecules of the TIGIT checkpoint as well as of the purinergic pathway are aberrantly expressed by BM-infiltrating CD8<sup>+</sup> T cells, NK cells and macrophages and also functionally relevant for tumor cell lysis.
Authors
- Katja Christina Weisel (ORCID: https://orcid.org/0000-0001-9422-6614)
- Jörg Krüger (ORCID: https://orcid.org/0000-0003-2632-9448)
- Julian Kylies
- Leon-Gordian Leonhardt
- Jasmin Wellbrock (ORCID: https://orcid.org/0000-0001-8067-2314)
- Lennart Viezens (ORCID: https://orcid.org/0000-0001-9353-667X)
- Friedrich Koch‐Nolte (ORCID: https://orcid.org/0000-0003-1730-6674)
- Franziska Brauneck (ORCID: https://orcid.org/0000-0002-0026-3658)
- Carsten Bokemeyer (ORCID: https://orcid.org/0000-0001-6071-7810)
- Michael D. Kruppa (ORCID: https://orcid.org/0000-0002-1747-2333)
- Walter Fiedler (ORCID: https://orcid.org/0000-0003-0275-8803)
- Stephan Menzel (ORCID: https://orcid.org/0009-0005-4742-9335)
- Niklas Kruppa
- Elias Brauneck
- Y. Wahid
- Anne Marie Assemissen
Institutions
- University of Bonn (DE)
- Universität Hamburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- University Cancer Center Hamburg (DE)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1007/s00262-025-04030-2
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Hamburger Krebsgesellschaft
- Deutsche Wirbelsäulenstiftung