Placental and Fetal In Utero Growth Among Fetuses With Congenital Heart Disease
In this case-control study of fetuses with and without CHD, those with CHD demonstrated impaired fetal body growth with higher fetal to placental volume ratios and smaller total brain volume, suggesting that placental failure was associated with growth disturbances in CHD, as demonstrated by the large fetal to placental volume ratios. Additional studies should assess the onset and progression of placental dysfunction and how the timing of placental failure may contribute to neurodevelopmental disability in survivors of CHD.
Authors
- Adré du Plessis (ORCID: https://orcid.org/0000-0003-3144-8791)
- Mary T. Donofrio (ORCID: https://orcid.org/0000-0002-0942-5481)
- Kushal Kapse (ORCID: https://orcid.org/0000-0001-8363-5404)
- Nickie Andescavage (ORCID: https://orcid.org/0000-0002-6812-7898)
- Catherine Limperopoulos (ORCID: https://orcid.org/0000-0003-1735-0069)
- Julius S. Ngwa (ORCID: https://orcid.org/0000-0002-6208-1331)
- Caitlin McDermott
- Josepheen De Asis‐Cruz (ORCID: https://orcid.org/0000-0003-3936-0380)
- Marin Jacobwitz (ORCID: https://orcid.org/0000-0002-9489-6594)
- Yao Wu (ORCID: https://orcid.org/0000-0003-0443-8571)
Institutions
- Children's National (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.7217
- Citations
- 7
- Primary Topic
- Congenital Heart Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 9.48
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development