Divergent Synthesis of Dihydrofuran and Dienol Scaffolds via Pd-Catalyzed Decarboxylative Carbene Cross-Coupling
Herein, we report a novel ligand-switchable Pd-catalyzed carbene coupling reaction employing vinylethylene carbonates and sulfoxonium ylides. By proper choice of ligands, the chemoselectivity of the process could be efficiently regulated, allowing for the availability of dihydrofuran or dienol scaffolds. This method features mild reaction conditions, broad scope, and remarkable synthetic utility. Compound <b>6f</b> can effectively stimulate the secretion of GLP-1, providing promising insight into the development of small-molecule agonists for the GLP-1 receptor.
Authors
- Weibo Yang (ORCID: https://orcid.org/0000-0003-1633-7655)
- Yi Zang (ORCID: https://orcid.org/0000-0001-9835-922X)
- Erfei Miao
- Chao-Ying Huang
- Yili Sun (ORCID: https://orcid.org/0000-0002-0198-2734)
- Ke‐Qiang Hou (ORCID: https://orcid.org/0000-0001-6640-9771)
- Tongyu Bi
- Lingyi Sun (ORCID: https://orcid.org/0000-0003-2111-8764)
- Xiaolong Ma (ORCID: https://orcid.org/0000-0003-2728-7817)
- Xun Zhang (ORCID: https://orcid.org/0000-0001-6538-9473)
- Zhongliang Xu
Institutions
- Shanghai University (CN)
- Nanjing University of Chinese Medicine (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Materia Medica (CN)
- Institute for Advanced Study (DE)
- University of Chinese Academy of Sciences (CN)
- Indiana University School of Medicine
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1021/acs.orglett.5c01198
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Postdoctoral Science Foundation of Shanghai Municipality