What does “appropriate scientific justification” mean for the review of human pluripotent stem cell, embryo, and related research?
This article complements the 2021 International Society for Stem Cell Research (ISSCR) Guidelines for Stem Cell Research and Clinical Translation by explaining what "adequate and appropriate scientific justification" means for human pluripotent stem cell, embryo, and related research, thus providing practical advice for review and oversight bodies, regulators, and investigators who conduct research in these areas.
Authors
- Kaori Muto (ORCID: https://orcid.org/0000-0001-5286-4706)
- Yoshihiro Kato (ORCID: https://orcid.org/0000-0001-9006-9551)
- Misao Fujita (ORCID: https://orcid.org/0000-0001-7919-5362)
- Megan Munsie (ORCID: https://orcid.org/0000-0003-3588-8321)
- Insoo Hyun (ORCID: https://orcid.org/0000-0001-6605-7112)
- Leigh Turner (ORCID: https://orcid.org/0000-0001-7283-6809)
- Jeremy Sugarman (ORCID: https://orcid.org/0000-0001-7022-8332)
- Rosario Isasi (ORCID: https://orcid.org/0000-0002-4937-7007)
- Erica C. Jonlin (ORCID: https://orcid.org/0000-0002-1082-0358)
- Krishanu Saha (ORCID: https://orcid.org/0000-0003-2837-0858)
- Kathy K. Niakan (ORCID: https://orcid.org/0000-0003-1646-4734)
Institutions
- Museum of Science (US)
- University of Wisconsin–Madison (US)
- University of Miami (US)
- California Institute for Regenerative Medicine (US)
- University of California, Irvine (US)
- Kyoto University (JP)
- University of Cambridge (GB)
- Johns Hopkins Berman Institute of Bioethics (US)
- Stem Cell Institute (PA)
- Murdoch Children's Research Institute (AU)
- RIKEN Center for Integrative Medical Sciences (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Stem Cell Reports
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1016/j.stemcr.2025.102479
- Citations
- 6
- Primary Topic
- Biomedical Ethics and Regulation
- Type
- article
- Field-Weighted Citation Impact
- 6.99
Funders
- International Society for Stem Cell Research