A Comprehensive Assessment of Metagenomic cfDNA Sequencing for Microbe Detection
This study presented the performance of metagenomic cfDNA sequencing in real-world settings, identifying key factors critical for its development and optimization. These findings provide valuable guidance for accurate pathogen detection in infectious diseases and promote the adoption of metagenomic cfDNA sequencing in diagnostics.
Authors
- Tao Huang (ORCID: https://orcid.org/0000-0001-5897-4017)
- Zhenli Diao
- Yuqing Chen (ORCID: https://orcid.org/0000-0002-5592-9197)
- Lei Feng (ORCID: https://orcid.org/0000-0003-2963-5336)
- Rui Zhang (ORCID: https://orcid.org/0000-0003-4660-2042)
- Jinming Li (ORCID: https://orcid.org/0000-0002-1476-3397)
- Yu Ma (ORCID: https://orcid.org/0000-0003-1807-8458)
- Yanxi Han
- Zihong Zhao
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Beijing Hospital (CN)
- National Center for Clinical Laboratories (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Clinical Chemistry
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1093/clinchem/hvaf044
- Citations
- 4
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 3.75
Funders
- National Key Research and Development Program of China