Administration of L-type Bovine Spongiform Encephalopathy to Macaques to Evaluate Zoonotic Potential
We administered L-type bovine spongiform encephalopathy prions to macaques to determine their potential for transmission to humans. After 75 months, no clinical symptoms appeared, and prions were undetectable in any tissue by Western blot or immunohistochemistry. Protein misfolding cyclic amplification, however, revealed prions in the nerve and lymphoid tissues.
Authors
- Hanae Takatsuki
- Tsuyoshi Mori
- Hiroaki Shibata
- Morikazu Imamura (ORCID: https://orcid.org/0000-0002-7010-6228)
- Ryuichiro Atarashi (ORCID: https://orcid.org/0000-0001-8381-0508)
- Haruo Iguchi
- Minoru Tobiume (ORCID: https://orcid.org/0000-0001-9110-2915)
- Fumiko Ono (ORCID: https://orcid.org/0000-0002-7317-9027)
- K. Hagiwara (ORCID: https://orcid.org/0000-0002-1948-6034)
- M. Ohno
Publication Details
- Journal
- Emerging infectious diseases
- Published
- 2025-04-24
- DOI
- https://doi.org/10.3201/eid3105.241257
- Citations
- 1
- Primary Topic
- Prion Diseases and Protein Misfolding
- Type
- article
- Field-Weighted Citation Impact
- 0.81